The purpose of the immune system is to allow us to live in harmony with our environment. In fact, most of the trillions of foreign cells present within our body coexist peacefully, and in some cases even contribute to our health and well-being. In spite of this, chronic diseases such as allergies, asthma, and eczema, which were rare several decades ago, have risen exponentially, especially in children, quadrupling during the last two decades.

The number of asthma sufferers in the United States is expected to double by the year 2020, affecting 1 in every 14 people and outnumbering the combined projected populations of New York and New Jersey. A growing number of scientists now believe that the routine measures taken to suppress and prevent infections actually weaken certain responses of a child’s immune system, allowing other less appropriate responses to operate without control. The reduction of childhood diseases has been heralded as one of medicine’s finest accomplishments, yet there are growing suspicions that infection intervention may be having an adverse effect; as childhood infections have decreased, chronic afflictions have increased.

The immune system has two different aspects: the cell-mediated immune system and the humoral immune system. The cell-mediated immune system involves white blood cells and specialized immune cells which “eat” antigens, or foreign particles in the body. This helps drive the antigens out of the body causing symptoms such as skin rashes and the discharge of pus and mucous from the throat and lungs. The cell-mediated response is associated with the beneficial acute inflammatory illnesses of children, and represents the externalization, or driving out of the infection.

The other aspect is called the humoral immune system whereby antibodies—special defense proteins—are produced to recognize and neutralize the antigen. It is a persistent humoral response that is associated with chronic allergic-type diseases.

In order to be healthy, a child must keep a balance between the cell-mediated system and the humoral system, with the cell-mediated system predominating. The cell-mediated response is activated by the natural exposure to bacteria and viruses, in the way children are exposed by interacting with their friends. Through repeated exposure to infectious organisms a child develops a diverse repertoire of immune response patterns. It is the cellmediated response that protects a child from future illness, and develops the type of immune response we commonly associate with life-long immunity. The cell-mediated system suppresses the activity of the humoral system. The more active the cell-mediated activity is, the less active the humoral system is.

However, if the cell-mediated system is not properly stimulated it does not fully develop, leading to an abnormally high production of humoral system antibodies. A humoral system that is continually engaged will overdevelop, creating a hypersensitive environment. When infants are exposed to germs early, their immune systems are pushed to go in an “infection-fighting direction.” Without this push, the immune system’s shift to infection fighting is delayed, and it becomes more likely to overreact to allergens—dust, mold, and other environmental factors that most people can tolerate.

Early life experiences are believed to play a crucial role in the formation and patterning of a child’s immune system. Sensitization begins in utero and the first few months of life are crucial, for once cell-mediated/humoral imbalance occurs it tends to persist until specific measures are taken to shift the immune system back to equilibrium. There are several ways that pattern the reaction of the immune system toward either the cell-mediated response or the humoral response based on their timing and frequency. The important thing for a parent to understand is that their child’s immune system will react based on the way it has been patterned and programmed to react. If your child’s current immune capacity is poor, then it is possible to improve it by making better choices in the future.

Hygiene

There are numerous reports that suggest the excessive cleanliness practiced in modern society may be partly responsible for the increased incidence of allergic diseases. Repeated exposure while young to various types of bacteria and spores found in dirt, dust, and animal dander may actually protect against the development of allergies. A molecule known as an endotoxin naturally occurs in the outer membrane of bacteria. When the bacteria die the endotoxin is released into the environment. Children are exposed to these endotoxins by breathing them in, or by ingesting them when they put their hands or other objects into their mouths. The exposure to bacteria, viruses, and endotoxins is essential for the maturation of the immune system; less exposure leads to imbalanced immune responses.

Children’s early exposure to allergens and infections prime their immune systems to resist them later on. Although children in daycare seem to get sick more often than other children do, this is not necessarily a bad thing. These colds and other infections may be giving their immature immune systems a health workout, resulting in a lower incidence of asthma. Children with the highest degree of personal hygiene are the most likely to develop eczema and wheezing between the ages of two and a half and three and a half years. In 2000, a study of 61 infants between the ages of 9–24 months found that the more house dust an infant was exposed to, the less likely that they would suffer allergies.

Antibiotics

Antibiotics given in the first year of life quadruple a child’s risk of developing asthma. Children given antibiotics after age one year are still one and a half times more likely to develop asthma than children not given antibiotics. What is particularly concerning is that every course of antibiotic treatments a child increases the occurrence of allergies and that treatment with broad spectrum antibiotics, such as streptomycin, tetracycline, and Cipro®, appear to be more likely to be associated with allergy development than is ordinary penicillin.

Antibiotics enhance allergic reactions by sidestepping the normal immune system response. Whenever the immune system successfully deals with an infection it emerges from the experience stronger and better able to confront similar threats in the future. Through the process of developing and then conquering infection, the child gets rid of acquired toxins and poisons from the body and receives a boost to the immune system. If you always jump in with antibiotics at the first sign of infection you do not give the immune system a chance to grow stronger.

Antibiotics also act nonspecifically, killing infectious bacteria as well as upsetting the normal gut flora. Substances that are introduced through the mouth are normally ignored by the humoral system. But, in order for this to occur, the normal bacteria in the intestines need to be present. Alterations in the normal intestinal bacteria levels, especially in infancy, allow food proteins and other particles to pass into the blood stream before they are broken down, where the body identifies them as a threat, contributing to a persistent humoral response and the development of allergic diseases.

Vaccination

Most childhood infections are caused by viruses, and thus do not respond to antibiotics, hence the development of our current vaccine program. Infections contracted naturally are ordinarily filtered through a series of immune system defenses. Naturally-contracted viral diseases stimulate a cell-mediated response, and it appears that because of this, early viral infections are protective against allergic diseases. When a vaccine is injected directly into the blood stream, it gains access to all of the major tissues and organs of the body without the body’s normal advantage of a total immune response. This results in only partial immunity, consequently the need for “booster” shots. Vaccines stimulate a humoral response so their contents are never discharged from the body, the way they would be if the disease were naturally contracted, leaving the body in a chronic state of sensitization. In a study of 448 children, 243 had been vaccinated against whooping cough. Of these, 10% had asthma compared to less than 2% of the 205 children in the non-vaccinated group, suggesting that the pertussis vaccination can increase the risk of developing asthma by more than five times.

Source:  pathwaystofamilywellness.org